Research Advances

Research is under way to explain the biological actions of PCP and the architecture of a receptor known as NMDA receptor complex. The NMDA complex has been implicated in the process of cell death in the nervous system. PCP has been found to block the NMDA-operated ion channels, thereby indirectly blocking the receptor that responds to glutamate, a normal chemical messenger. This may give a clue to deciphering the cause of schizophrenia.

In addition, research has determined that PCP can protect the brain from permanent damage after a stroke or heart attack. Basic brain research on the actions of amino acids and the effects of commonly abused drugs led to the discovery that PCP can stop the uncontrolled activity that destroys nerve cells. This discovery is expected to help people who suffer from any trauma that interrupts the supply of oxygen to the brain. Researchers are now looking for drugs that can work like PCP without producing the psychological effects.

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